In 2006, Don broke the morale of his associates and became the undisputed King of the underworld. Having conquered the Asian underworld, Don (Shahrukh Khan) now has his sights set on European domination. In his way are the bosses of the existing European underworld and all law enforcement agencies. The action shifts from Kuala Lumpur to Berlin as Don must avoid assassination or arrest in order for his plan to succeed.
Shahrukh Khan – Don: A 'wanted' man, 5 years ago, he was being hunted by law enforcement agencies of 11 countries. After a cat-and-mouse game of his own archestration, where he duped everyone into believing that he was the paan-chewing simpleton Vijay. Don walked away victorious as the invincible king of Asian underworld. This time around, wilier and even more ruthless than before, Don is ready for bigger game. A master plan that will destroy all his enemies and virtually bring Europe to its knees!
Priyanka Chopra – Roma: She wants to avenge the murder of her brother Ramesh at the hands of Don, she fell in love with Don's innocent look alike Vijay... only to shockingly discover that Vijay was actually Don. Now, determined to seek vengeance, she has joined the Interpol and is part of their worldwide hunt for Don. When she does find him, will it be payback time for Don?
Boman Irani – Vardhaan: He was masquerading as DCP De'Silva and the dual identity was all part of an elaborate subterfuge. Singhania had double-crossed him and Vardhaan managed to settle the score by assassination. But his best-laid plans hadn't taken into account Don's scheming mind. Now, he's languishing in a Malaysian prison, waiting... seething... to get even with Don. But when Don comes calling with a hand held out in friendship, will he join forces with his arch enemy?
Om Puri – Mallik: An Interpol officer, his life's mission seems to be the capture of Don. He's spent years pursuing him. Now, also a mentor to Roma, he is willing to do all it takes to accomplish what he started out to do. But when he does come face-to-face with Don, will he manage to apprehend him?
Rajesh Khattar – Singhania: Singhania had entrusted the running of his drug cartel to his trusted lieutenant Don. But Don had always has other plans. He took Singhania out of the equation with a major stroke by getting Vardhaan to do the fatal job and took over the cartel. Although Singhania still has a part to play in Don's destiny. He has left behind a safety deposit box in Switzerland. The contents of which hold the key to Don's new master plan.