Hrithik Roshan: He plays Arjun in the film. He is a financial trader working with a huge firm in London. Being brought up without a father, he has seen the dark side of life. He is reluctant to go on a holiday with his friends due to his tight work schedule but agrees to go.
Farhan Akhtar: In the film, Farhan is Imraan, a copywriter working with an advertising agency. His aim is to go to Spain.
Abhay Deol: In the film, Abhay plays Kabir, wealthy young man, who works in his father's construction company. He is engaged to Natasha.
Katrina Kaif: Katrina is a fashion student from London. She meets three young Indian guys while she is in Spain.
Kalki Koechlin: She is an interior designer and daughter of a rich hotelier. She is in love with Kabir and is engaged to him.
Synopsis: Zindagi Na Milegi Dobara is about three young Indians played by Hrithik Roshan (Arjun), Abhay Deol (Kabir) and Farhan Akhtar (Imraan). Their holiday together changes their lives forever.
Kabir is engaged to Natasha but he wants to go for a bachelor party and decided to go on a three week road trip with his school friends Arjun and Imraan. Arjun is busy with his work yet he finds time for the trip. Finally, they set off for the much-anticipated and delayed holiday. What happens during and after their holiday forms the rest of the story.