2008 - Best Ensemble Cast for Synecdoche, New York (2008) Shared with Philip Seymour Hoffman, Samantha Morton, Michelle Williams, Catherine Keener, Jennifer Jason Leigh, Dianne Wiest, Emily Watson, Tom Noonan Tied with Vicky Cristina Barcelona (2008).
Independent Spirit Awards
2009 - Robert Altman Award for Synecdoche, New York (2008) Shared with Charlie Kaufman (director), Jeanne McCarthy (casting director), Philip Seymour Hoffman, Jennifer Jason Leigh, Catherine Keener, Samantha Morton, Tom Noonan, Emily Watson, Dianne Wiest, Michelle Williams
New York Film Critics Circle Awards
2003 - NYFCC Award - Best Actress for American Splendor (2003) Also for The Secret Lives of Dentists (2002).
Seattle Film Critics Awards
2003 - Seattle Film Critics Award - Best Actress for American Splendor (2003)