Burlesque tells the story of a retired dancer Tess (Cher), who owns the Burlesque Lounge. It is about her struggle to keep the theatre alive among artistic and financial challenges.
In the meantime, Ali Rose (Christina Aguilera) enters the scene with a small town background. She leaves her waitress gown to prove her talent on stage. She approaches Tess and tries to impress her with failed attempts. However, she gets selected a waitress by Tess. But the big dream of Ali and her vocal range impresses pianist Jack (Cam Gigandet), who allows her to crash at his place.
One day, Ali’s talent is unveiled by Nikki (Kristen Bell) and she turns centre of attraction of a shrewd businessman named Marcus Gerber (Eric Dane). Gerber wants to acquire the lounge from Tess but this does not go well with Jack, who is not sure about his feelings for Ali.