The 'Meet The Parents' funnyman has been selected as the recipient of the prestigious award for giving cinemagoers some of the funniest characters of the last decade, including Zoolander, Gaylord Focker and Tugg Speedman.
The 43-year-old comic started his career with his own MTV series in the early 1990s, but it was subsequently cancelled after one season.
However, the actor fondly remembers his time at the channel, and jokingly confessed that he romanced veteran MTV presenter J.J. Jackson.
"I am honoured to be getting the Generation Award. I was given my first show at MTV and also cancelled for the first time. I also was secretly having an affair with J.J. Jackson, so it brings back pleasant memories," the Daily star quoted him as saying.
The Golden Popcorn prizes, nominated and voted for by MTV viewers, will be handed out in Los Angeles on May 31.