Talking to MTV, Judd Apatow hinted on Justin Bieber's cameo. The Get Him to the Greek producer said, "I can't really tell [what the cameo is], but he makes an appearance toward the end of the film. He doesn't know about it yet, so if you're watching this, Justin!" He added, "There's a party scene in the film that I think will have a lot of the stars. We just wrote President Obama into them. We have an offer out to him."
However, actor Paul Reubens, who created and portrayed the iconic character since 1980s, has written the script for the Pee-wee Herman movie. The comedian said that he wrote the script with Apatow's collaborator Paul Rust. They reportedly make it to be in the mold of the first film 'Pee-wee's Big Adventure'.