The Creative Community For Peace's document has been signed by Hollywood stars who want violent clashes between Israeli forces and Palestinian troops in Gaza to end.
In the statement, the stars urge politicians to find a resolution and end the fighting, while they also come out in support of Israel and criticise the Palestinian Hamas organisation.
The letter reads, "We, the undersigned, are saddened by the devastating loss of life endured by Israelis and Palestinians in Gaza.
"We are pained by the suffering on both sides of the conflict and hope for a solution that brings peace to the region...
"While we stand firm in our commitment to peace and justice, we must also stand firm against ideologies of hatred and genocide...
"We join together in support of the democratic values we all cherish and in the hope that the healing and transformative power of the arts can be used to build bridges of peace."
Other stars to have signed the statement include Kelsey Grammer, Minnie Driver and Mayim Bialik.