Aptharakshaka is the sequel of the super hit Apthamithra. Soundarya was the heroine of Apthamithra; Aptharakshaka has five heroines: Bhavana, Lakshmi Gopalaswamy, Nikita, Vimala Raman and Sandya. The supporting cast includes veteran actor Srinivasamurthy who will again play the head of the family, and Avinash, who is retained in the role of the 'Mantravadi".
Apthamithra, which was a remake of the Malayalam film Manichithrathazhu, is based on Multiple Personality Disorder. This was Soundarya's last film. (She was killed in a plane crash in 2004.) This hugely successful film was remade in Tamil as Chandramukhi with Rajinikanth in the lead role.