Grand Mother movie tells Kalyaniamma (KPAC Lalitha) who had raised eight children and with age fast catching up with her. She has to somehow find ways to again be the center of the drama that is life. This often ends up in creating misunderstanding and fights between the members. The only fears that haunt Kalyaniamma are the fears of loneliness and fear of being neglected. Sensing her insecurities, her children fix a home nurse, Usha (Athira) , for her. Grandma hates her. Slowly Usha works through the blocks.
A desire crept into her - she wanted Usha to marry her youngest son, Gopikuttan (Jagadish) . When this was happening, Gopikuttan was seriously considering a matrimony proposal from another girl and the marriage was fixed. Kalyaniamma didn't like that - How she goes ahead and fulfills her desire forms the rest of the story.