Manassil Oru Manjuthulli movie is based on the story of Mohandas (Krishna Kumar) who loves Maya ( Praveena), but is forced to marry another girl Manika for his sister’s sake. During their honeymoon trip he meets with an accident and goes into coma. When he doesn’t come out of coma even after three years, his mother and others convince Manika to marry Manoj, a friend of Mohandas.
Meanwhile, Maya, who was in Delhi, returns. She still loves Mohandas. What happens next is dealt with by the film.