Manikuttan is supported by Nazar Thirur, Sai Kumar, Vijayaraghavan, Suraj Venjaramoodu, Salim Kumar, Cochin Haneefa, Indrans, Rajan.P.Dev, Janardhanan, Augustin, Mamu Koya, Machan Vargeese, Narayanan, Kochu Preman, Kaviyoor Ponnamma, Githa Nair, Kulapulli Leela, Kozhikode Sarada and others.
Panthaya Thamburan is directed by debutant Ram Mohandas casting Manikuttan as the hero. The screenplay is also written by Ram Mohandas. Under the banner of Guru movies, Nazar is producing this film. Lyrics are by Kaithapram Damodharan Namboothiri and Sarat has scored the music. P.Sukumar will wield the camera.