Puli Vesham has RK taking on a different role in anti-negative role. He plays the role of a person, who is ready to do anything for money and lands up bumping off any bigwigs in town.
And then, there is a sincere assistant commissioner of police (Karthik) looking out for a right opportunity to bump off few persons, who were responsible for the death of his close friend. He assigns the job to RK and makes sure everything goes perfectly.
A girl (Sadha) with a mysterious past pretending to be a desolated person comes to RK. These three characters are coalesced together and it forms crux of the story.