The show's complainants will range from married or long-term relationships, and will also include both opposite-sex and same-sex couples. The show's cameras have captured a number of unusual incidents. In one of the most cited examples was that of host Joey Greco being stabbed by an angry suspect who was confronted on a boat.
A wife discovers that her husband is infatuated with another woman, who is already in a prior relationship. A woman discovers that her lesbian lover is sleeping with a man behind her back.
A born again Christian woman, who has asked her fiance to remain celibate until their wedding, discovers that he has been flouting his celibacy vows with another woman.
A man suspects that his girlfriend's supposedly gay male friend is not actually gay, and that their friendship is actually much more than that. A woman is suspicious of her truck driver boyfriend and wants confirmation of his cheating ways.
A college student is afraid that his long distance relationship may be in jeopardy, as his girlfriend seems to have distanced herself from him ever since he moved to a different college. A homemaker is afraid that her boyfriend, the father of her second child may be cheating behind her back.
A young woman is afraid that her recent weight loss has caused her boyfriend to lose interest in her. Cheaters finds out that he prefers full figured women. A woman is afraid that her female lover may be hiding something from her - Cheaters reveals some of the most shocking evidence of infidelity ever seen on the show.