Apthudu is a action based movie In which, Gangireddy (Mukesh Rushi) who is a powerful mafia leader in Hyderabad. His latest mission is to grab a colony. Bose (Raja Sekhar) visits his brother (Chandrasekhar) who stays in the same colony that Gangireddy has his sights on. When the colony dwellers decide to give up everything and surrender to Gangireddy, Bose makes a difference by uniting them and fight for the cause. In the process, Gangireddy kills Bose's brother and father. The rest of the story is all about how Bose takes revenge on Gangireddy.