Letha Manasulu is an remake version of Tamil movie Azhagi and this movie is an Family Romance based movie. In which, Raju (Srikanth) and Dhana Lakshmi (Kalyani) are childhood friends. They love each other and never express it. As the fate has it, Dhana Lakshmi gets married to another guy. Raju gets married to a rich girl called Bhanu (Gopika). Later on, Dhana Lakshmi encounters a tragedy and becomes a poor widow. She starts doing daily labor to feed herself and her kid. Raju comes across her on a road one day and feels pity after realizing her fate. He gives her a job as a maidservant at his house by hiding the fact to his wife that Dhanalakshmi was his childhood friend. The rest of the film is about what happens if Bhanu comes to know that Raju and Dhanalakshmi were childhood friends and had crush for each other at one point of time.