Nenu Pelliki Ready is an Romance based movie. In which, Gopi (Srikanth) is pressurized by his grand parents to get married. But Gopi wants to make sure that there is compatibility with the girl he is going to marry. Hence, he approaches a marriage bureau and selects the profiles of three girls and meets them as a friend. These three girls are Savitri (Anitha) - a freelancing journalist, Bhavana (Laya) - a classical danseuse and Neha (Vidya) - a bank employee. Subsequently, all these three girls fall in love with Gopi and want to marry him. Gopi wants to get rid of these three girls now. Entire second half revolves around how Gopi gets rid of them and incidentally lends his marriage hand to the owner of marriage bureau Priya (Sangeeta). Rest of the movie is about who will he marry?