Rami Reddy was introduced by director Kodi Ramakrishna in Ankusham, which went to become a blockbuster. Before entering the film industry, he worked as a journalist in several Urdu and Hindi news papers. He done his PG in Journalism from Osmania University.
He acted nearly 250 films in Tamil, Telugu, Kannada, Hindi and Malayalam. Gaayam, Anaganaga Oka Roju, Ammoru, Peddrikam, Osey Ramulamma, Jagadeka Veerudu Atiloka Sundari, Anji are some of his notable films in the Telugu film industry.