Ninaithale Inikkum story is about a group of college friends and problems faced by them. Shakthi with his golden voice is the doyen of the college campus. Prithviraj is a firebrand student leader with leanings towards the left. Karthik Kumar leads the opposite faction. Priyamani is the daughter of the local MLA and a danseuse who wins numerous awards for the college with her performance. Bhagyaraj is the lecturer.
Ninaithale Inikkum film follows lead actor Kamal Hassan who plays a singer and his band on a tour to Singapore. Over there Kamal meets his love interest (played by Jaya Pradha), only to find that she is terminally ill. The film ends on a tragic note with the lady's demise.