Vismayathumbathu is a psychological thriller movie. Sreekumar (Mohanlal) who is endowed with the quality to see spirits and imps. When he comes to the city, the house his friends Govindan Kutty (Mukesh) and Chandran (Harisree Asokan) find for him houses a spirit. Mohanlal after some mirthful-moments with his friends finds out that the spirit belongs to that of Reena Mathews (Nayantra). She turns out to be a medical student, whom everyone is searching for.
How did she go missing, and what happened to her forms the rest of the story.