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Produced by Devgan Films and directed by Ajay Devgan, U, Me Aur Hum is a special love story of Ajay (Ajay Devgan) and Pia (Kajol). The first time Ajay saw Pia, she served him drinks. She affected him more than the alcohol, and he found true love. He was a leading psychiatrist, but she messed up his mind. The first time Pia saw Ajay, he had had too much to drink.
She watched him make a fool of himself, and was relieved when he passed out. She was a woman who followed her heart, but despite his claims of true love, she had made up her mind. Thus began the story of Ajay and Pia.