Pistha is yet another mass entertainer with Vishal paired up with Shreya. Muralikrishna (Vishal) who lives in the village with his mother (Gita) decides to leave for Vizag, in search of his elder brother Rambabu, who had left the House in his childhood. While searching for his brother in Vizag, Murali comes across Indu (Shreya). Sooner they fall in love with one another. Unexpectedly Murali get entangled in the cobweb of two goons in the city, Ramakrishna (Prakash Raj) and Guru. Murali witnesses a murder perpetrated by Guru and Ramakrishna, Guru's opponent, wants to cash in on that.
Murali learns from an orphanage that a person by name Rambabu (Sriman) had stayed there for some time and is presently working as an RDO. Once Murali accidentally comes across Rambabu, who is being chased and attacked by Guru.