Naa Upiri film is about two persons, Venu (Naveen) and Gowri (Sangeetha) are orphans and childhood friends. Venu is very innocent. Gowri is his guardian angel. They live together since their childhood. They get married to each other once they enter 20's. Venu works as a supervisor and Gowri is housewife. They have a kid called Ramu. Slowly it is revealed that Venu is suffering from a psychological disorder called schizophrenia, in which a person could see imaginary things and believe that they are real. Madhu (Anjana) enters into his life as a girl who needs affection. The rest of the story is all about why Madhu entered his life.