The action comedy is about a CIA operative, Susan Cooper (Melissa McCarthy), whose desk job is about to turn into a field agent. Susan is CIA analyst guiding her partner, Agent Bradley Fine (Jude Law) on a mission to Bulgaria from the CIA office in the US.
While she is doing a perfect desk job as Fine's guiding analyst, she is self-deprecating as she desires to try some field job. From the very beginning, Spy will give you the humour when Fine accidentally shoots his target due to pollen in the room which makes him sneeze and ultimately fire the pistol.
What follows next is a rib tickling comedy with lots of twists.