Manmadhan Ambu is yet another deadly combination of superstar Kamal Hassan and director KS Ravikumar. The duo has always given some big hits to the industry and this is going to be one more addition to that list. The film also stars talented actors like Madhavan, Ramesh Aravind, Trisha, Sangeetha and Urvashi in important roles. For the first time, Trisha is acting with Kamal's film and Madhavan is also uniting with the veteran after their critically acclaimed film Anbe Sivam in 2003.
The film has more than half of the scenes shot across Europe and a on a cruise ship. Manmadhan Ambu tells the story of three individuals, Major Mannar (Kamal Haasan), Ambujakshi (Trisha) and industrialist Madhan Gopal (Madhavan). Actress Sangeetha essays the role of a divorcee woman Deepa, who has two kids. She is a close friend of Ambujakshi. Oviya plays the cousin of Madhan.