Late one night, British animal rights activists break into a science laboratory to free chimpanzees being used for medical research. Disregarding the warnings of the local scientist, the activists ultimately free the Rage virus subjects, which attack and infect the activists and scientist. Twenty-eight days later, a bicycle courier named Jim (Cillian Murphy) awakens from a coma in a deserted hospital. As he leaves the hospital, he discovers London is completely deserted and rife with signs of catastrophe. Jim is soon discovered and chased through the streets by infected people before being rescued by two survivors, Selena (Naomie Harris) and Mark (Noah Huntley), who rush him to their hideout in the London Underground. They reveal that while Jim was comatose, the virus spread uncontrollably among the populace, turning most people into vicious monsters ("the Infected") and resulting in societal collapse, possibly on a global scale.