Nee Premakai is a tringular love story in which, Srinivas (Vineeth) and Prabhu (Abbas) are roommates. Srinivas is a sincere guy working in BATA as manager. Prabhu is a parasite, who uses the money and room of Srinivas for his own luxury.
Both these guys have a pious and beautiful neighbor in the form of Anjali (Laya). Srinivas sincerely loves her. Srinivas sends money (Rs 10,000/-) for Anjali as an anonymous well wisher, since her father could not afford MCA education for Anjali.
Prabhu takes the credit by pretending to be that anonymous well wisher. Prabhu exploits Srinivas to the maximum and uses it to attract Anjali. At the same time, Prabhu creates such a situation where Anjali start hating Srinivas.
A relative of Srinivas (Brahmanandam) talks with the parents of Anjali and makes them agree to marry off Anjali to Srinivas. But when Anjali comes to know about this, she says that she is in love with Prabhu. Rest of the story is how Anjali come to know about the who is true well wisher.